Cyclopeptolide inhibitors of adhesion molecules

Details Cyclopeptolide inhibitors of adhesion molecules Cyclopeptolide inhibitors of adhesion molecules

C - Chemistry, Metallurgy

12

N

C12N 1/14 (2006.01) A61K 9/06 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 38/15 (2006.01) C07K 7/06 (2006.01) C07K 11/00 (2006.01) C07K 11/02 (2006.01) C12P 21/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2192786

Cyclopeptolides of formula I (see formula I) wherein A, B, R1Leu, Leu, C, X and Y are as defined, are inhibitors of adhesion molecule expression and are thus useful for treatment of inflammatory and other diseases which involve increased levels of adhesion molecule expression.

Des cyclopeptolides de formule (I), dans laquelle A, B, R1Leu, Leu, C, X et Y sont définis dans le descriptif de l'invention, sont des inhibiteurs de l'expression des molécules d'adhérence et servent, par conséquent, dans le traitement de maladies inflammatoires et autres comportant l'accroissement du degré d'expression des molécules d'adhérence.

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