Cyclopeptolide inhibitors of adhesion molecules

Details Cyclopeptolide inhibitors of adhesion molecules Cyclopeptolide inhibitors of adhesion molecules

C - Chemistry, Metallurgy

12

N

C12N 1/14 (2006.01) A61K 38/15 (2006.01) A61P 37/00 (2006.01) C07K 11/02 (2006.01) C12P 21/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2237157

Cyclopeptolides of formula (I), wherein A, B, R1Leu, Leu, C, X and Y are as defined, are inhibitors of adhesion molecule expression and inhibitors of TNF release and are thus useful for treatment of inflammatory and other diseases which involve increased levels of adhesion molecule expression and/or are mediated by TNF.

L'invention concerne des cyclopeptolides de la formule (I). Dans cette formule A, B, R1Leu, Leu, C, X et Y correspondent à la définition donnée dans la description. Ces composés sont des inhibiteurs de l'expression des molécules d'adhésion et de la libération du facteur TNF et ce sont donc des agents utiles pour le traitement de maladies inflammatoires et d'autres maladies liées à une expression excessive des molécules d'adhésion et/ou induites par le facteur TNF.

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