Cyclophosphamide - sodium bicarbonate lyophilizates

A - Human Necessities – 61 – K

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167/250

A61K 31/665 (2006.01) A61K 9/19 (2006.01) A61K 31/675 (2006.01) A61K 47/02 (2006.01)

Patent

CA 2001552

A stable rapidly dissolving lyophilized composition of cyclophosphamide and sodium bicarbonate is provided which contains an amount of water which is equimolar to the amount of cyclophosphamide and sodium bicarbonate in said composition; the composition is preferably prepared from a solution containing at least 3% (W/V) weight sodium bicarbonate.

Composition lyophilisée stable et à dissolution rapide, de cyclophosphamide et de bicarbonate de sodium, renfermant une quantité d'eau équimolaire par rapport à la quantité de cyclophosphamide et de bicarbonate de sodium présente dans la composition; la composition est préparée de préférence à partir d'une solution renfermant au moins 3 % (P/V) en poids de bicarbonate de sodium.

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