Cyclopropachromen derivatives

Details Cyclopropachromen derivatives Cyclopropachromen derivatives

C - Chemistry, Metallurgy

07

D

260/279.37, 260/

C07D 311/94 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2037187

CYCLOPROPACHROMEN DERIVATIVES ABSTRACT OF THE DISCLOSURE: A cyclopropachromen derivative represented by formula (I): Image (I) wherein n represents an integer of 2 to 5; R1 and R2 inde- pendently represent a hydrogen atom or an alkyl group having from 1 to 5 carbon atoms, a phenyl group or an aralkyl group having 7 to 10 carbon atoms, or alternatively R1 and R2 form together with the nitrogen atom. to which they are attached, a morpholino group, a thiomorpholino group, a pyrrolidinyl group, a piperidinyl group, a homopiperidinyl group, a piperazinyl group, a homopiperazinyl group, an N- alkylpiperazinyl group, N-alkylhomopiperazinyl group, an N-hydroxyalkylpiperazinyl group or a pyrrolidonyl group or alternatively R1 and R2 form together with the nitrogen atom to which they are attached, and further a carbon atom to which said nitrogen atom is bound, a pyrrolitidinyl group; A1 and A2 independently represent a hydrogen atom, a hydroxyl group, a halogen atom or an optionally substituted alkoxy group, B1 and B2 independently represent a hydrogen atom, a hydroxyl group, a halogen atom or an optionally substituted alkoxy group; provided that where R1 and R2 both represent a hydrogen atom, A1, A2, B1 and B2 on the two benzene rings all represent a hydrogen atom or, otherwise, the two substituents on at least one benzene ring have the meaning other than a hydrogen atom, and a pharmaceutically acceptable salt thereof are disclosed. The compounds are useful as improving and treating agents for cerebral organic disorders and psychic function disorders.

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