C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/506 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2742007
Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including, but not limited to, malignant melanomas, solid tumors, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, hepatic cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, chronic myelogenous leukemia, leukemias, papillary thyroid carcinoma, non-small cell lung cancer, mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, diabetic retinopathy, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocytosis, mast cell leukemia, and diseases caused by PDGFR-.alpha. kinase, PDGFR-.beta. kinase, c-KIT kinase, cFMS kinase, c-MET kinase, and oncogenic forms, aberrant fusion proteins and polymorphs of any of the foregoing kinases.
L'invention concerne des composés qui trouvent une utilité dans le traitement de cancers de mammifères, et en particulier de cancers humains, comprenant, sans s'y limiter, les mélanomes malins, les tumeurs solides, les glioblastomes, le cancer de l'ovaire, le cancer du pancréas, le cancer de la prostate, les cancers du poumon, les cancers du sein, les cancers du rein, les cancers du foie, les carcinomes cervicaux, les métastases de sites de tumeur primaire, les maladies myéloprolifératives, la leucémie myéloïde chronique, les leucémies, le carcinome papillaire thyroïdien, le cancer du poumon non à petites cellules, le mésothéliome, le syndrome hyperéosinophile, les tumeurs stromales gastro-intestinales, les cancers du côlon, les maladies oculaires caractérisées par une hyperprolifération aboutissant à la cécité, notamment diverses rétinopathies, la rétinopathie diabétique, la polyarthrite rhumatoïde, l'asthme, les maladies pulmonaires obstructives chroniques, la mastocytose, la leucémie mastocytaire et les maladies provoquées par la PDGFR-a kinase, la PDGFR-ß kinase, la c-KIT kinase, la cFMS kinase, la c-MET kinase, des formes oncogéniques, des protéines de fusion aberrantes et des polymorphes de l'une quelconque des kinases précédentes.
Flynn Daniel L.
Kaufman Michael D.
Petillo Peter A.
Deciphera Pharmaceuticals Llc
Deeth Williams Wall Llp
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