Cyclopropyl beta-amino acid derivatives

Details Cyclopropyl beta-amino acid derivatives Cyclopropyl beta-amino acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 229/46 (2006.01) A61K 31/195 (2006.01)

Patent

CA 2513150

This invention relates to novel cyclopropyl .beta.-amino acids derivatives of the formula (I) wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl .beta.- amino acids derivatives of this invention exhibit activity as alpha2delta ligands (.alpha.2.delta. ligands). Such compounds have affinity for the .alpha.2.delta. subunit of a calcium channel.

L'invention a trait à de nouveaux dérivés d'acides .beta.-aminés de cyclopropyle de formule (I), dans laquelle R?1¿ jusqu'à R?4¿ sont définis tels que dans la spécification, à des compositions pharmaceutiques les contenant et à leur utilisation dans le traitement de divers troubles du système nerveux central et d'autres troubles. Les dérivés d'acides .beta.-aminés de cyclopropyle de cette invention présentent une activité en tant que ligands alpha2delta (.alpha.2? ligands). De tels composés possèdent une affinité vis-à-vis de la sous-unité .alpha.2? d'un canal calcique.

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