C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/10 (2006.01) A61K 31/422 (2006.01) A61P 31/04 (2006.01) C07D 263/20 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2529293
This invention relates to new oxazolidinones, having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi- resistant staphylococci, streptococci and enterococci, Bacteroides spp., Clostridia spp. species, as well as acid-fast organisms such as Mycobacterium tuberculosisand other mycobacterial species. The compounds are represented by structural formula (I) its enantiomer, diastereomer, or pharmaceutically acceptable salt or ester thereof.
L'invention concerne des nouveaux oxazolidinones comprenant un fragment cyclopropyle, efficaces contre des pathogènes aérobies et anaérobies de type staphylocoques, streptocoques et entérocoques multirésistants, espèces Bacteroides spp., Clostridia spp., ainsi que contre des organismes acido-alcoolo-résistants de type Mycobacterium tuberculosis et d'autres espèces mycobactériennes. Les composés de l'invention sont représentés par la formule structurale (I), cette formule pouvant également représenter un énantiomère, un diastéréoisomère, un sel ou un ester acceptable sur le plan pharmaceutique desdits composés.
Kyorin Pharmaceutical Co. Ltd.
Merck & Co. Inc.
Robic
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