C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/22 (2006.01) A61K 31/41 (2006.01) A61P 31/04 (2006.01) C07D 263/20 (2006.01) C07D 413/06 (2006.01) C07D 413/10 (2006.01) C07D 413/12 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2463794
This invention relates to new oxazolidinones having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi- resistant staphylococci, streptococci and enterococci, Bacteroides spp., Clostridia spp. species, as well as acid-fast organisms such as Mycobacterium tuberculosis and other mycobacterial species. The compounds are represented by structural formula (I): its enantiomer, diastereomer, or pharmaceutically acceptable salt or ester thereof.
L'invention concerne des nouveaux oxazolidinones présentant un fragment de cyclopropyle, qui sont efficaces contre des pathogènes aérobies et anaérobies de type staphilocoques, streptocoques et enterocoques multirésistants, des espèces bactéroïdes spp. et clostridia spp., ainsi que des organismes acido-résistants de typeMycobacterium tuberculosis et autres espèces mycobactériennes. Les composés de l'invention sont représentés par la formule générale (I). L'invention concerne également des énantiomères, diastéréomères, ou sels ou esters pharmaceutiquement acceptables desdits composés.
Kyorin Pharmaceuticals Co. Ltd.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Robic
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