C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 275/64 (2006.01) A61K 31/16 (2006.01) A61K 31/395 (2006.01) C07C 259/06 (2006.01) C07C 323/44 (2006.01) C07C 323/47 (2006.01) C07D 295/15 (2006.01)
Patent
CA 2124835
Compounds of formula (1) wherein A is C1 to C3 alkylene, Ar is phenyl or styryl, R is halosubstituted C1 to C3 alkyl, NHR' or (II), R' is hydrogen or C2 to C8 alkylthioalkyl, n is an integer of from 1 to 4 and p is an integer of from 2 to 5, with the proviso that when R' is hydrogen then Ar is styryl, and the pharmaceutically acceptable salts thereof, inhibit the enzyme lipoxygenase and are useful in treating allergy and inflammatory and cardiovascular conditions for which the action of lipoxygenase has been implicated. These compounds form the active ingredient in pharmaceutical compositions for treating such conditions.
Composés de formule (1) où A est un alkylène C1 à C3, Ar est un phényle ou un styryle, R est un alkyle C1 à C3 avec halosubstitution, NHR' ou (II), R' est un hydrogène ou un alkylthioalkyle C2 à C8, n est un entier de 1 à 4 et p un entier de 2 à 5, à la condition que si R' est de l'hydrogène, alors Ar est un styryle; leurs sels acceptables en pharmacie. Ces produits sont des inhibiteurs de l'enzyme lipoxygénase; ils servent à traiter les allergies et les troubles inflammatoires et cardiovasculaires, où l'action de la lipoxygénase joue un rôle. Ils sont les ingrédient actifs de compositions permettant de traiter ces troubles.
Ikeda Takafumi
Kawai Akiyoshi
Mano Takashi
Okumura Yoshiyuki
Stevens Rodney W.
Limited Pfizer
Smart & Biggar
LandOfFree
Cyclopropyl n-hydroxyureas and n-hydroxyacetamides which... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclopropyl n-hydroxyureas and n-hydroxyacetamides which..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclopropyl n-hydroxyureas and n-hydroxyacetamides which... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1986634