Cyclopropyl-piperazine compounds as calcium channel blockers

Details Cyclopropyl-piperazine compounds as calcium channel blockers Cyclopropyl-piperazine compounds as calcium channel blockers

C - Chemistry, Metallurgy

07

D

C07D 295/182 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) C07D 401/08 (2006.01) C07D 403/08 (2006.01) C07D 403/12 (2006.01) C07D 413/08 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2666275

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type calcium channel activity are disclosed. Specifically, a series of compounds containing both a piperazine ring and a cyclopropyl ring are disclosed of the general formula (I) where X1 and X2 are linkers.

L'invention concerne des procédés et des composés efficaces pour améliorer des conditions caractérisées par une activité indésirée des canaux calciques, en particulier une activité indésirée des canaux calciques de type N. De manière spécifique, une série de composés contenant à la fois un noyau pipérazine et un noyau cyclopropyle sont décrits, représentés par la formule générale (I) dans laquelle X1 et X2 sont des bras de liaison.

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