C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/00 (2006.01) C07D 211/68 (2006.01) C07D 211/80 (2006.01) C07D 213/02 (2006.01)
Patent
CA 2581582
The present invention is directed to cyclopropyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.
La présente invention concerne des composés de piperidine de cyclopropyle qui permettent d'inhiber le transporteur de glycine GlyT1 et qui sont utilisés dans le traitement de troubles neurologiques et psychiatriques liés à un dysfonctionnement de la neurotransmission glycinergique ou glutamatergique et de maladies, au cours desquelles est impliqué le transporteur de glycine GlyT1.
Lindsley Craig W.
Wisnoski David D.
Wolkenberg Scott E.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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