Cyclopropylacetonitrile derivatives, preparation thereof and...

C - Chemistry – Metallurgy – 07 – C

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C07C 255/42 (2006.01) A61K 31/275 (2006.01) A61K 31/36 (2006.01) C07C 255/43 (2006.01) C07D 317/64 (2006.01)

Patent

CA 2162916

Compounds of general formula (I), wherein R¿1?-R¿3? and R¿6?-R¿8? are, in particular, fluorine, chlorine, methyl, ethyl, isopropyl, tert-butyl, methoxyl and ethoxyl radicals, R¿4? is hydrogen or lower alkyl, and R¿5? is an optionally substituted phenyl or phenoxy radical; for use as calcium channel antagonists and serotonin 5-HT¿2? antagonists, and particularly as neuroprotective agents.

Les composés de l'invention répondent à la formule générale (I), dans laquelle: R1 à R3 et R6 à R8 représentent notamment des radicaux fluor, chlore, méthyle, éthyle, isopropyle, tert-butyle, méthoxyle et éthoxyle; R4 est un hydrogène ou un alkyle inférieur; R5 est un radical phényle ou phénoxy éventuellement substitué. Application comme antagonistes des canaux calcium et antagonistes de la sérotonine 5-HT2 en particulier comme neuroprotecteurs.

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