Cyclopropylmethyloxybenzimidazoles

Details Cyclopropylmethyloxybenzimidazoles Cyclopropylmethyloxybenzimidazoles

C - Chemistry, Metallurgy

07

D

167/237, 260/277

C07D 401/12 (2006.01) A61K 31/415 (2006.01)

Patent

CA 1262137

CYCLOPROPYLMETHYLOXYBENZTMIDAZOLES ABSTRACT OF THE DISCLOSURE Benzimidazole derivatives of the general formula [I] are provided: Image [I] wherein R1 is hydrogen, methyl or methoxy, and R2 and R3 each is hydrogen or methyl, at least one of R1, R2 and R3 being a member other than hydrogen. The benzimidazole derivatives exhibit an excellent activity of inhibiting the potassium ion-dependent adenosine triphosphatase, as well as a good stability during storage. Therefore, the benzimidazole derivatives are usable for the treatment of gastric and/or duodenal ulcers.

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