Cyclopropylpyrroloindole-oligopeptide anticancer agents

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 38/04 (2006.01) C07D 487/10 (2006.01) C07K 5/027 (2006.01)

Patent

CA 2210093

The invention is directed to novel cyclopropylpyrroloindole-oligopeptide compounds which are useful as anticancer agents. The novel cyclopropylpyrroloindole-oligopeptide compounds have general structure (I), wherein Het1 and Het2 are individually selected from the group consisting of pyrrole, imidazole, triazole, thiophene, furan, thiazole, oxazole and pyrazole, R is selected from the group consisting of a valence bond; a C1-C6 alkyl; a C2-C6 alkenyl; a C2-C6 alkynyl; and an ortho, meta or para linked aromatic group, A is selected from the group consisting of a C1-C6 alkyl group; and amidine or derivative thereof; a guanidine; a secondary, tertiary or quaternary ammonium salt; and a sulfonium salt, n is 0 to 3, and m is 0 to 3.

La présente invention concerne de nouveaux composés de cyclopropylpyrrolo-indole-oligopeptides qui sont utiles comme agents anticancéreux et dont la structure générale est donnée par la formule (I) dans laquelle Het?1¿ et Het?2¿ sont choisis individuellement dans le groupe constitué par le pyrrole, l'imidazole, le triazole, le thiophène, le furane, le thiazole, l'oxazole et le pyrazole, R est choisi dans le groupe constitué par une liaison de valence, un alkyle C¿1?-C¿6?, un alcényle C¿2?-C¿6?, un alcynyle C¿2?-C¿6? et un groupement aromatique à liaison ortho, méta ou para, A est choisi dans le groupe constitué par un groupement alkyle C¿1?-C¿6?, une amidine ou un dérivé d'amidine, une guanidine, un sel d'ammonium secondaire, tertiaire ou quaternaire et un sel de sulfonium, n est égal à 0 à 3, et m est égal à 0 à 3.

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