Cyclosporin-containing soft capsule preparations

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/13 (2006.01) A61K 9/107 (2006.01) A61K 9/48 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2226091

The present invention relates to a cyclosporin-containing soft capsule preparation which comprises a composition containing cyclosporin as an active ingredient; a hydrophilic component polyethylene glycol or a non-hydrophilic component propylene carbonate or their mixture, a mixture of an esterified compound of fatty acid and primary alcohol, medium chain fatty acid triglyceride and fatty acid monoglyceride as an oil component; and a surfactant having an HLB (Hydrophilic Lipophilic Balance) value of 8 to 17, in a gelatin shell containing polyethylene glycol and propylene glycol as a plasticizer.

L'invention concerne une préparation de gélules molles contenant de la cyclosporine, qui comprend comme principe actif une composition contenant de la cyclosporine; comme composant huileux un composant hydrophile polyéthylène glycol ou un composant non hydrophile carbonate de propylène, ou leur mélange, un mélange d'un composé estérifié d'un acide gras et d'un alcool primaire, un triglycéride d'acide gras à chaîne moyenne et un monoglycéride d'acide gras; et un agent tensioactif ayant un rapport hydrophile-lipophile compris entre 8 et 17, dans une coque de gélatine contenant comme plastifiant du polyéthylène glycol et du propylène glycol.

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