Cyclosporin derivative with modified "8-amino acid"

Details Cyclosporin derivative with modified "8-amino acid" Cyclosporin derivative with modified "8-amino acid"

C - Chemistry, Metallurgy

12

P

195/128.1, 167/1

C12P 21/04 (2006.01) A61K 38/13 (2006.01) C07K 7/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1338319

A new cyclosporin derivative with incorporated "8-(3-fluoro-D-alanine)" or "8-(2- deutero-3-fluoro-D-alanine)" has been isolated from the fermentation broth of incubating Tolypocladium inflatum MF5080 (NRRL 8044) with 3-fluoro-D-alanine or its 2-deuterated isomer respectively. The modified cyclosporins exhibit immunosuppressive properties.

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