Cyclosporins

Details Cyclosporins Cyclosporins

C - Chemistry, Metallurgy

07

K

167/205, 195/89,

C07K 7/64 (2006.01) A61K 31/395 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1247546

-1- ABSTRACT Cyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy-.alpha.-amino acid residue, typically of formula Image wherein X = -MeBmt- or -dihydro-MeBmt-, Y = -.alpha.Abu-, -Ala-, -Thr-, -Val- or -Nva-, Z = -Val- or -Nva- and Q = R1-CO-O-CH(R2)- CH(CO-)-NH- wherein R1 = H, C1-4alkyl or phenyl and R2 = H or CH3, possess immunosuppressive, anti-inflammatory and anti- parasitic activity.

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