A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 36/28 (2006.01) A61P 1/00 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2614796
The present invention relates to the preparation of a Cynara scolymus extract obtainable by fractioning on a resin. The process of the invention allows to obtain an extract, starting from the aerial parts of the plant Cynara scolymus, containing three classes of active principles, namely dicaffeoylquinic acids, luteolin and cynaropicrin glycosides, in a constant ratio. Cynaropicrin is stabilized by addition of precise amounts of sulfated amino acids or suitable thio-derivatives. These extracts have hypolipemizing, anti-dyspeptic and vascular anti-inflammatory activities. The extracts are mainly formulated in Enothera biennis oil or in oils rich in .omega.-3 and .omega.-6 acids which enhance the vascular activity.
La présente invention concerne la préparation d'un extrait de Cynara scolymus pouvant être obtenu par fractionnement sur une résine. Le procédé de l'invention permet d'obtenir un extrait, à partir des parties aériennes de la plante Cynara scolymus, contenant trois classes de principes actifs, à savoir des acides dicafféoylquiniques, des glycosides de lutéoline et de cynaropicrine, dans un rapport constant. La cynaropicrine est stabilisée par addition de quantités précises d'acides aminés sulfatés ou de thio-dérivés appropriés. Ces extraits ont des activités vasculaires hypolipémiantes, antidyspeptiques et anti-inflammatoires. Les extraits sont principalement formulés dans l'huile d'Oenothera biennis ou dans des huiles riches en acides .omega.-3 et .omega.-6 qui améliorent l'activité vasculaire.
Arpini Sabrina
Bombardelli Ezio
Fontana Gabriele
Giori Andrea
Morazzoni Paolo
Gowling Lafleur Henderson Llp
Indena S.p.a.
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