Cyp1b1 nucleic acids and methods of use

Details Cyp1b1 nucleic acids and methods of use Cyp1b1 nucleic acids and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) A61K 31/7088 (2006.01) A61K 45/06 (2006.01) A61K 47/30 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2427340

The present invention provides nucleic acids containing transcriptional units that encode CYP1B1 polypeptides or portions thereof, wherein the transcriptional units lack sequences found in the untranslated region (UTR) of naturally occurring forms of the CYP1B1 transcript. Then nucleic acids of the invention lack translational repressor elements and thus provide for a system of enhanced translation of the CYP1B1 polypeptide or portions thereof. Also disclosed are methods of administering nucleic acids to a mammal and use in the treatment of proliferative disorders or cancer.

La présente invention concerne des acides nucléiques contenant des unités transcriptionnelles qui codent des polypeptides CYP1B1 ou des parties de ceux-ci, les unités transcriptionnelles présentant un manque des séquences trouvées dans la région non traduite (UTR) de formes naturelles du produit de transcription de CYP1B1. Les acides nucléiques selon cette invention présentent un manque d'éléments de répression de traduction, ce qui permet d'obtenir un système de traduction améliorée du polypeptide CYP1B1 ou de parties de celui-ci. La présente invention concerne également des procédés pour administrer des acides nucléiques à un mammifère, ainsi que leur utilisation dans le traitement de maladies prolifératives ou du cancer.

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