Cyp3a4 nfse variant and methods of use therefor

Details Cyp3a4 nfse variant and methods of use therefor Cyp3a4 nfse variant and methods of use therefor

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 9/02 (2006.01) C12P 19/34 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2339524

A nucleic acid sequence encoding a variant CYP3A4 gene is provided. Also provided are methods and kits for identifying individuals carrying a variant CYP3A4 gene with a heightened risk of developing or having prostate cancer or a decreased risk for developing treatment-related leukemias and identifying more effective and safer treatment regimes for individuals based upon their CYP3A4 genotype.

L'invention concerne une séquence d'acides nucléiques codant un gène allélomorphe CYP3A4, ainsi que des procédés et trousses servant à identifier des individus porteurs d'un tel gène allélomorphe et ayant un cancer de la prostate ou présentant un risque accru de développement d'un tel cancer, ou un risque moindre de développement de leucémies associées à un traitement, et à identifier des schémas de traitement plus efficaces et sûrs, destinés à des individus en fonction de leur génotype CYP3A4.

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