Cyp7 promoter-binding factors

Details Cyp7 promoter-binding factors Cyp7 promoter-binding factors

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12N 1/00 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2311281

The invention provides methods and compositions relating to CPF proteins which regulate transcriptional activation, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed CPF encoding nucleic acids or purified from human cells. The invention provides isolated CPF hybridization probes and primers capable of specifically hybridizing with the disclosed CPF genes, CPF-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

L'invention concerne des méthodes et des compositions se rapportant à des protéines CPF lesquelles régulent l'activation transcriptionnelle, ainsi qu'aux acides nucléiques associés. Les polypeptides peuvent être produits par recombinaison à partir de cellules hôtes transformées provenant des acides nucléiques codant le CPF décrit ou purifiées à partir de cellules humaines. L'invention concerne également des sondes et des amorces d'hybridation du CPF isolées capables de s'hybrider spécifiquement aux gènes du CPF décrits, des agents de liaison spécifiques du CPF tels que des anticorps spécifiques, et des méthodes de production et d'utilisation des compositions de l'invention en diagnostic, en thérapie et dans l'industrie biopharmaceutique.

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