C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/435 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2546623
Disclosed are Cystatin C (CysC) homologues, including CystC homologues that act as antagonists or inhibitors of transforming growth factor-.beta. (TGF- .beta.). Also disclosed are methods to identify CystC homologues that are antagonists or inhibitors of TGF-.beta. and compositions and therapeutic methods using CystC and homologues thereof to regulate the activity of TGF- .beta., and TGF--.beta.mediated tumor malignancy and invasion and other TGF-- .beta.mediated fibrotic or proliferative conditions and diseases.
L'invention porte sur des homologues de Cystatine C (CysC), y compris des homologues de CystC qui agissent en tant qu'antagonistes ou inhibiteurs du facteur de croissance transformant .beta. (TGF-.beta.). Elle a aussi trait à des procédés d'identification d'homologues de CystC qui sont des antagonistes ou des inhibiteurs de TGF-.beta. et à des compositions et des procédés thérapeutiques utilisant CystC et des homologues de celle-ci afin de réguler l'activité de TGF-.beta., et des tumeurs malignes et des invasions induites par TGF-.beta., ainsi que d'autres conditions et maladies fibreuses ou proliférantes induites par TGF-.beta..
Gowling Lafleur Henderson Llp
National Jewish Medical And Research Center
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