Cysteic acid derivatives of anti-viral peptides

Details Cysteic acid derivatives of anti-viral peptides Cysteic acid derivatives of anti-viral peptides

C - Chemistry, Metallurgy

07

K

C07K 14/16 (2006.01)

Patent

CA 2687700

This invention relates to C34 peptide derivatives having improved aqueous solubility that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory synctial vims (RSV), human parainfluenza virus (HPV), measles virus (MeV). and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.

L'invention concerne des dérivés de peptides C34 présentant une solubilité accrue en milieu aqueux, qui sont des inhibiteurs d'infection virale et/ou qui possèdent des propriétés anti-fusogéniques. Plus particulièrement, l'invention concerne des dérivés de C34 présentant une activité inhibitrice contre le virus de l'immunodéficience humaine (VIH), le virus respiratoire syncytial (VRS), le virus parainfluenza humain (HPV), le virus de la rougeole (MeV) et le virus de l'immunodéficience simienne (VIS), avec une longue durée d'action pour le traitement des infections virales correspondantes.

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