C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/24 (2006.01) C07K 14/54 (2006.01) C12N 1/21 (2006.01)
Patent
CA 2111327
2111327 9301212 PCTABS00019 Muteins of IL-6 and truncated IL-6 are prepared by recombinant DNA techniques. In the muteins, the cysteine residues that occur at positions, or at positions corresponding to positions, 45 and 51 of mature, native IL-6 have been replaced by other amino acids. The cysteine residues that occur at positions, or at positions corresponding to positions, 74 and 84 are retained. The molecule has biological activity that is at least comparable to that of native IL-6.
Fowlkes Dana M.
Skelly Susan M.
Snouwaert John N.
Tackney Charles T.
Gowling Lafleur Henderson Llp
Imclone Systems Incorporated
University Of North Carolina At Chapel Hill
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