Cysteine-depleted muteins of biologically active proteins

Details Cysteine-depleted muteins of biologically active proteins Cysteine-depleted muteins of biologically active proteins

C - Chemistry, Metallurgy

12

N

195/1.22, 195/1.

C12N 15/19 (2006.01) A61K 51/08 (2006.01) C07K 14/52 (2006.01) C07K 14/55 (2006.01) C07K 14/565 (2006.01) C12N 15/10 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340861

Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been replaced with other amino acids, or in the case of IFN-.beta. deleted or replaced with other amino acids, to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. These muteins are made via bacterial expression of mutant genes that encode the muteins that have been synthesized from the genes for the parent proteins by oligonucleotide-directed mutagenesis.

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