Cysteine engineered antibodies for site-specific conjugation

Details Cysteine engineered antibodies for site-specific conjugation Cysteine engineered antibodies for site-specific conjugation

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C12N 15/13 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2711736

Cysteine engineered antibodies useful for the site-specific conjugation to a variety of agents are provided. Methods for the design, preparation, screening, selection and use of such antibodies are also provided.

La présente invention concerne des anticorps obtenus par la cystéine, utiles pour la conjugaison spécifique d'un site à une variété d'agents. L'invention concerne également des procédés de conception, de préparation, de criblage, de sélection et d'utilisation de ces anticorps.

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