Cysteine mutants and methods for detecting ligand binding to...

Details Cysteine mutants and methods for detecting ligand binding to... Cysteine mutants and methods for detecting ligand binding to...

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C12N 9/00 (2006.01) G01N 33/48 (2006.01) G01N 33/68 (2006.01) G06F 17/30 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2454246

The present invention relates generally to variants of target biological molecules ("TBMs") and to methods of making and using the same to identify ligands of TBMs. More specifically, the invention relates to individual variant TBMs and sets of variant TBMs, each of which represents a modified version of a protein of interest where a thiol has been introduced at or near a site of interest. Ligands of TBMs are identified in part through the formation of a covalent bond between a potential ligand and a reactive thiol on the TBM.

D'une manière générale, la présente invention se rapporte à des variantes de molécules biologiques cibles (<= TBM >=), et à des procédés de production et d'utilisation de ces dernières, permettant d'identifier des ligands desdites TBM. Plus précisément, l'invention se rapporte à des variantes particulières de TBM et à des ensembles de variantes de TBM, dont chacune représente une version modifiée d'une protéine d'intérêt, dans laquelle un thiol a été introduit au niveau ou à proximité d'un site d'intérêt. Des ligands de TBM sont identifiés, en partie par la formation d'une liaison covalente entre un ligand potentiel et un thiol réactif situé sur la TBM.

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