Cysteine protease inhibitors with 2-cyano-4-amino-pyrimidine...

Details Cysteine protease inhibitors with 2-cyano-4-amino-pyrimidine... Cysteine protease inhibitors with 2-cyano-4-amino-pyrimidine...

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07D 239/42 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2456127

The invention provides compounds of formula I or a pharmaceutically acceptable salt or ester thereof (I), wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find use pharmaceutically for treatment of diseases and medical conditions in which cathepsin K is implicated, e.g. various disorders including inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis and tumors.

La présente invention concerne des composés de formule (I) ou un sel ou ester de ceux-ci, acceptable d'un point de vue pharmaceutique. Dans la formule (I), les symboles ont les correspondances indiquées. Lesdits composés sont des inhibiteurs de cathepsine K et trouvent des applications pharmaceutiques dans le traitement de troubles et d'états pathologiques dans lesquels la cathepsine K est impliquée, par ex. différents troubles comprenant l'inflammation, l'arthrite rhumatoïde, l'ostéoarthrite, l'ostéoporose et les tumeurs.

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