Cysteine thiol-protected peptides for use in immunoassays

Details Cysteine thiol-protected peptides for use in immunoassays Cysteine thiol-protected peptides for use in immunoassays

C - Chemistry, Metallurgy

07

K

C07K 14/155 (2006.01) C07K 1/107 (2006.01) C07K 7/04 (2006.01) C07K 14/16 (2006.01) C07K 17/02 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2056381

Peptides immunoreactive with antibodies to native proteins, and which have at least two cysteine residues that contribute to mimicking an epitope of the protein, are prepared with the cysteine thiol groups protected. When deprotected, the peptides have enhanced immunoreactivity. The peptides are particularly useful for detecting antibodies or antigens associated with retroviruses, including the clinically important lymphotropic retroviruses HIV-1, HIV-2, HTLV-I, and HTLV-II.

On prépare des peptides capables de réagir immunologiquement avec des anticorps de protéines natives, ayant au moins deux résidus de cystéine qui aident à simuler un épitope de la protéine, avec des groupes protégés thiols de cystéine. Lorsqu'ils ne sont pas protégés, ces peptides présentent une immunoréactivité accrue. Ces peptides sont particulièrement utiles pour détecter des anticorps ou des antigènes associés à des rétrovirus, y compris les rétrovirus lymphotropes VIH-1, VIH-2, HTLV-I et HTLV-II, qui ont une importance clinique particulière.

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