C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
150/13, 150/15.1
C12Q 1/32 (2006.01) G01N 33/50 (2006.01)
Patent
CA 1116501
Abstract of the Disclosure A method of diagnosing cystic fibrosis, identi- fying carriers for cystic fibrosis, and non-carriers or "normal" persons. Heretofore, no carrier or prenatal de- dection method procedure for cystic fibrosis existed. The detection is based on the discovery of the genetic abnor- mality or biochemical defect in cystic fibrosis, which occurs in mitochondria, minute bodies found in the cyto- plasm of most cells which are the principal energy source of the cell and contain the cytochrome enzymes of terminal electron transport. The method comprises an assay carried out on preparations derived from human cells possessing mitochondria. The assay may be a kinetic assay of the enzyme complex of the energy conserving site of the mito- chondrial electron transport system of the cells or an assay of mitochondrial activity governed by the enzyme complex. The assay is then evaluated by comparison with standards established as the result of similar assays of cells of other subjects of known condition. The assays provide determination of characteristics which differ in the three types of individuals (normal, carrier, and affected) and provide a basis for their distinction.
350006
Barrigar & Moss
The Regents Of The University Of Minnesota
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