Cytochrome c protein and assay

Details Cytochrome c protein and assay Cytochrome c protein and assay

C - Chemistry, Metallurgy

07

K

C07K 14/80 (2006.01) C12N 5/10 (2006.01) C12N 15/67 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2549523

The present invention relates to a a cytochrome c-reporter fusion protein construct comprising a modified cytochrome c protein which targets the mitochondria and has a reduced ability to induce apoptosis in a living cell. The invention also relates to nucleic acid constructs encoding such protein fusions and cells stably transfected with such constructs. The stably transfected cells of the invention can be used in assays to detect apoptosis.

L'invention concerne une construction de protéine de fusion rapporteur cytochrome c qui comprend une protéine cytochrome c modifiée qui cible les mitochondries et qui présente une capacité réduite à induire l'apoptose chez une cellule vivante. L'invention concerne également des constructions d'acides nucléiques codant pour lesdites protéines de fusion et des cellules transfectées de manière stable par lesdites constructions. Lesdites cellules transfectées de manière stable peuvent être utilisées dans des analyses afin de détecter l'apoptose.

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