Cytochrome p-450 gene cluster from rhodococcus ruber and...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/09 (2006.01) B09C 1/10 (2006.01) C07K 14/79 (2006.01) C07K 16/12 (2006.01) C07K 16/40 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) C12N 9/02 (2006.01) C12Q 1/68 (2006.01) C12S 1/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2451002

The present invention is directed to a cytochrome P-450 gene cluster involved in the cleavage of ether fuel additives. More especially, the present invention pertains to the nucleic acid sequence of genes responsible for the biodegradation of ethyl tert-butyl ether (ETBE) in Rhodococcus ruber, and to several applications ensuing from the knowledge of this sequence, such as probes and biosensors for detecting a pollution by an ether fuel, and for assessing the potential of a contaminated soil to cleave said ether fuel. The invention also pertains to methods for rendering a cell able to cleave ether fuel additives, and to recombinant bacteria useful for ether fuel depollution of a contaminated effluent.

La présente invention concerne une batterie de gènes du cytochrome P-450 impliquée dans le clivage des additifs pour éther carburant. En particulier, l'invention concerne la séquence nucléotidique de gènes responsables de la biodégradation de l'éthyl tertio-butyl éther (ETBE) chez Rhodococcus ruber, et plusieurs applications découlant de la connaissance de ladite séquence, comme par exemple, des sondes et des biocapteurs permettant de détecter une pollution causée par un éther carburant, et permettant d'évaluer le potentiel de clivage d'éther carburant d'un sol contaminé. L'invention se rapporte également à des procédés permettant de rendre une cellule capable de cliver les additifs pour éther carburant, et à des bactéries recombinées utilisées pour dépolluer un effluent contaminé de l'éther carburant.

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