Cytochrome p450 oxidase inhibitors and uses thereof

Details Cytochrome p450 oxidase inhibitors and uses thereof Cytochrome p450 oxidase inhibitors and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 277/24 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61P 43/00 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2661873

The present invention features compounds of formula (I) or pharmaceutically acceptable salts, solvates or prodrugs thereof, and describes methods of using the same to inhibit the metabolizing activities of CYP enzymes. The present invention also describes methods of using these compounds, salts, solvates or prodrugs to improve the pharmacokinetics of drugs that are metabolized by CYP enzymes.

La présente invention concerne des composés représentés par la formule I ou des sels, des solvates ou des promédicaments pharmaceutiquement acceptables de ces composés et des procédés d'utilisation de ces derniers pour inhiber les activités de métabolisation des enzymes CYP. Cette invention porte également sur des procédés d'utilisation de ces composés, ces sels, ces solvates ou ces promédicaments pour améliorer la pharmacocinétique des médicaments qui sont métabolisés par les enzymes CYP.

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