Cytokeratin tumor markers and assays for their detection

Details Cytokeratin tumor markers and assays for their detection Cytokeratin tumor markers and assays for their detection

C - Chemistry, Metallurgy

12

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167/37, 530/15.0

C12P 21/08 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 5/18 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 1336171

Methods and compositions are provided for iden- tifying patients suffering from neoplastic diseases such as breast cancer. It has been found that neoplastic epithelial cells, including neoplastic mammary epithelial cells, release a particular N-terminal blocked, soluble cytokeratin into circulation. The presence of this cytokeratin is diagnostic of neoplastic disease. Hybridoma cell line UCD/AB 611 was deposited at the American Type Culture collection on December 8, 1983 and granted accession no. HB 8458. Hybridoma cell line UCD/PR 10.11 was deposited at the American Type Culture Collection on January 3, 1985, and granted accession no. HB 8694.

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