Cytokine

Details Cytokine Cytokine

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2095840

ABSTRACT OF THE DISCLOSURE cDNA prepared by extracting mRNA from the interstitial cells of the human bone marrow was; expressed, after being cloned, with the cells of a mammal. A protein having an activity of inhibiting adipocyte formation was separated from the cell culture supernatant having such an activity and purified. The protein was found to have an apparent molecular weight of about 23,000 by conducting SDS-PAGE electrophoresis under a reducing condition and have an N- terminal proline residue as a result of identification of the N-terminal amino acid sequence by Edman degradation. The total primary structure of the protein was determined by the above-mentioned finding and the result of genetic cloning described above to reveal that it is a cytokine having an activity of inhibiting adipocyte formation and a new structure. Thus it has become possible to produce a novel adipocyte formation inhibitor in a large amount by the recombined DNA technology and to diagnose and treat various cytopeniae and other diseases.

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