Cytokine binding domains

Details Cytokine binding domains Cytokine binding domains

C - Chemistry, Metallurgy

07

K

C07K 14/715 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2549884

The present invention relates a method of generating modified binding moieties comprising a cytokine binding domain consisting of a first FnIII-like domain and a second FnIII-like domain in which at least one amino acid residue within the cytokine binding domain in modified such that the binding characteristics of the cytokine binding domain are altered, and/or, the solubility and/or stability of the binding moiety is improved. The invention also relates to binding moieties and to the use of such binding moieties as affinity reagents, diagnostic reagents, therapeutic agents and protein scaffolds.

La présente invention concerne un procédé permettant de produire des fragments de liaison modifiés comprenant un domaine de liaison à la cytokine qui consiste en un premier domaine de type FnIII et un second domaine de type FnIII, au moins un reste d'acide aminé dans le domaine de liaison à la cytokine étant modifié de telle sorte que les caractéristiques de liaison du domaine de liaison à la cytokine soient modifiées et/ou que la solubilité et/ou la stabilité du fragment de liaison soient améliorées. Cette invention concerne également des fragments de liaison ainsi que l'utilisation de tels fragments en tant que réactifs d'affinité, réactifs diagnostiques, réactifs thérapeutiques et squelettes protéiques.

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