Cytokine immunoconjugates

Details Cytokine immunoconjugates Cytokine immunoconjugates

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 47/48 (2006.01) C07K 14/52 (2006.01) C07K 14/525 (2006.01) C07K 14/535 (2006.01) C07K 16/06 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12N 15/19 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2095836

Immunoconjugates for the selective delivery of a cytokine to a target cell are disclosed. The immunoconjugates are comprised of an immunoglobulin heavy chain having a specificity for the target cell, such as a cancer or virus-infected cell, and a cytokine, such as lymphotoxin, tumor necrosis factor alpha, interleukin-2, or granulocyte-macrophage colony stimulating factor, joined via Aits amino terminal amino acid to the carboxy-Aterminus of the immunoglobulin. Nucleic acid sequences encoding these immunoconjugates and methods of their preparation by genetic engineering techniques are also disclosed.

Immunoconjugués destinés à acheminer sélectivement une cytokine à une cellule cible. Les immunoconjugués comprennent une chaîne lourde d'immunoglobulines ayant une spécificité vis-à-vis de la cellule cible, telle qu'une cellule cancéreuse ou infectée par un virus, ainsi qu'une cytokine, telle qu'une lymphotoxine, un facteur de nécrose tumorale alpha, de l'interleukine-2, ou un facteur stimulant les colonies de granulocytes macrophages, jointe par l'intermédiaire d'un acide aminé à terminaison amino Aits à la terminaison carboxy-A de l'immunoglobuline. L'invention concerne également des séquences d'acides nucléiques codant ces immunoconjugués ainsi que leurs procédés de préparation selon des techniques de génie génétique.

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