Cytokine inhibition of eosinophils

A - Human Necessities – 61 – K

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A61K 38/19 (2006.01)

Patent

CA 2512090

A composition and method to alter eosinophil function and recruitment. An allergen-induced chemokine with inhibitory activity on eosinophils, monokine induced by interferon y (MIG) and/or an IFN-y-inducible protein of 10 kDa (IP- 10), is administered in a pharmaceutically acceptable dose and formulation. The composition is used for prophylaxis and therapy of diseases in which eosinophilia occurs and may be administered, for example, to allergic patients and asthmatic patients.

L'invention concerne une composition et un procédé destinée à altérer la fonction et le recrutement des éosinophiles. Une chimiokine induite par un allergène à activité inhibitrice sur des éosinophiles, la monokine induite par un interféron .gamma. (MIG) et/ou une protéine pouvant être induite par un IFN-.gamma. de 10 kDa (IP-10), sont administrées à une dose et à une formulation pharmaceutiquement acceptables. La composition est utilisée pour la prophylaxie et la thérapie de maladies, dans lesquelles l'éosinophilie apparaît, et elle peut être administrée, par exemple, à des patients allergiques et des patients asmathiques.

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