Cytokine inhibitors

Details Cytokine inhibitors Cytokine inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/429 (2006.01) A61K 31/437 (2006.01) A61K 31/5025 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2704431

Imidazole compounds Formula I shown in the specification. Also disclosed are methods of using these compounds to decrease the level of a cytokine (e.g., TNF.alpha. or IL-1.beta.) in a subject and to treat a disorder mediated by an overproduction of a cytokine.

La présente invention concerne des composés d'imidazole de formule I montrée dans la spécification. L'invention décrit également des procédés permettant d'utiliser ces composés pour diminuer le niveau d'une cytokine (par exemple TNFa ou IL-1ß) chez un sujet et de traiter un trouble médié par une surproduction d'une cytokine.

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