Cytokine involved in epithelial-mesenchymal transition

Details Cytokine involved in epithelial-mesenchymal transition Cytokine involved in epithelial-mesenchymal transition

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) A61P 17/02 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2537473

The functional characterization of ILEI to be a cytokine involved in epithelial/mesenchymal transition and the identification of biologically active ILEI provides the basis for generating ILEI inhibitors, in particular anti-ILEI antibodies, that are useful in the therapy of cancer, fibrosis and COPD.

La caractérisation fonctionnelle d'ILEI pour une cytokine impliquée dans la transition épithéliale / mésenchymale et l'identification d'ILEI présentant une activité biologique fournit une base pour générer des inhibiteurs d'ILEI, en particulier d'anticorps anti-ILEI, qui sont utiles dans la thérapie du cancer, de la fibrose et de BPCO.

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