Cytokine modulators using cyclic glycerides of essential...

C - Chemistry – Metallurgy – 07 – D

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C07D 317/30 (2006.01) A61K 31/357 (2006.01) A61P 25/28 (2006.01) A61P 37/08 (2006.01) C07D 319/06 (2006.01)

Patent

CA 2598785

A method of treating a patient in need of therapy for a cytokine dysregulation comprising administering to that patient a therapeutically effective dose of a compound of general formula: (I) wherein R1 and R2 together form a group - (CH2)n-CR4R5-(CH2)m- wherein n and m are independently selected integers 0, 1 or 2 and R4 and R5 are independently selected from H, C1-18 alkyl, C1- 18alkoxy, C1-18n hyroxyalkyl, C2-18 alkenyl and C6-18aryl or aralykyl and R3 is the a fatty acyl group of an essential poyunsaturated fatty acid.

La présente invention décrit une méthode de traitement d'un patient nécessitant une thérapie pour un dérèglement de cytokines, ladite méthode de traitement comprenant l'administration à ce patient d'une dose thérapeutiquement significative d'un composé de formule générale : (I) où R1 et R2 forment ensemble un groupement -(CH2)n-CR4R5-(CH2)m- où n et m sont des entiers indépendamment sélectionnés parmi 0, 1 et 2 et R4 et R5 sont indépendamment sélectionnés parmi H, les groupements alkyle en C1-18, les groupements alkoxy en C1-18, les groupements n-hydroxyalkyle en C1-18, les groupements alcényle en C2-18 et les groupements aryle ou arylalkyle en C6-18, et R3 est un groupement acyle gras issu d'un acide gras essentiel polyinsaturé.

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