Cytokine production-inducing antibody

Details Cytokine production-inducing antibody Cytokine production-inducing antibody

G - Physics

01

N

G01N 33/68 (2006.01) A61K 39/395 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/80 (2006.01)

Patent

CA 2498315

The invention relates to a method of measuring the activation of an effector cell belonging to the immune system, which may or may not be transformed, using a monoclonal (AcMo) or polyclonal antibody. The invention is characterised in that it consists in: bringing into contact (i) CD16 receptor-expressing cells in a reaction medium in the presence of the antibody and (ii) the antigen of said antibody, and measuring the quantity of at least one cytokine produced by the CD16 receptor-expressing cell. The invention also relates to the selection of an antibody capable of inducing the expression of cytokines and interleukins, such as IFN? or IL2 which are intended for the treatment of autoimmune and inflammatory diseases, cancers and infections by pathogens.

La présente invention concerne un procédé pour mesurer l~activation d~une cellule effectrice appartenant au système immunitaire, transformée ou non, par un anticorps monoclonal (AcMo) ou polyclonal, caractérisé en ce qu~il comprend une mise en contact de cellules exprimant le récepteur CD16 dans un milieu réactionnel en présence de l~anticorps et de l~antigène dudit anticorps et une mesure de la quantité d~au moins une cytokine produite par la cellule exprimant le récepteur CD16. L~invention porte également sur la sélection d~anticorps présentant la caractéristique d~induire l~expression de cytokines et d~interleukines, notamment l~IFN.gamma. ou l~IL2 destinés au traitement des maladies autoimmunes et inflammatoires, des cancers et des infections par des agents pathogènes.

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