Cytokine receptor modulators and uses thereof

Details Cytokine receptor modulators and uses thereof Cytokine receptor modulators and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61P 9/10 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 14/52 (2006.01) C12N 15/11 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2650656

Non-competitive peptide antagonists of cytokine receptors, methods of their identification and therapeutic uses thereof are disclosed, wherein said peptides are between 7 and 20 ammo acids in length and derived from the extracellular regions of the msulm-like growth factor 1 receptor, human vascular endothelial growth factor receptor, human mterleukm-1 receptor, human mterleukm-4 receptor, human epidermal growth factor receptor or the human growth hormone receptor The compounds disclosed may be used for the treatment of cytokme-associated diseases such as proliferative disorders (colon, breast, prostate and lung cancer), abnormal neovascularization and angiogenesis, age related macular degeneration and proliferative and/or inflammatory skin disorders such as psoriasis

La présente invention concerne des composés de liaison au récepteur de la cytokine, tels que des peptides non compétitifs de liaison au récepteur VEGF, au récepteur IL-I, au récepteur IL-4, ou au récepteur IGF-I et des antagonistes pétidomimétiques, ainsi que des utilisations thérapeutiques de ces composés. Les composés de l'invention peuvent être utilisés pour traiter des troubles associés à la cytokine, tels que des troubles de prolifération (par exemple le cancer du colon, du sein, de la prostate et du poumon), la néovascularisation anormale, l'angiogenèse anormale, la dégénérescence maculaire liée à l'âge, et les problèmes de peau de prolifération et/ou inflammatoires tels que le psoriasis.

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