Cytokine receptor mouse zcytor10

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2372837

Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for mouse zcytor10, a novel mouse cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells. Ligand-binding receptor polypeptides can also be used to block ligand activity. The polynucleotides encoding mouse zcytor10 can be used to identify a human ortholog. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

L'invention concerne de nouveaux polypeptides, polynucléotides codant les polypeptides, ainsi que des compositions et procédés connexes destinés à un nouveau récepteur de cytokine de souris, zcytor10 de souris. On peut utiliser les polypeptides dans le cadre des procédés destinés à détecter des ligands qui stimulent la prolifération et/ou le développement de cellules hématopoïétiques, lymphoïdes et myéloïdes. Les polypeptides du récepteur de liaison des ligands peuvent également être utilisés pour bloquer l'activité du ligand. Les polynucléotides codant le récepteur zcytor10 de souris peuvent être utilisés pour identifier un orthologue humain. L'invention concerne également des procédés de production de la protéine, les utilisations associées et les anticorps correspondants.

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