Cytokine receptor zalpha11

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2343839

Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

On décrit de nouveaux polypeptides, des polynucléotides codant les polypeptides ainsi que des compositions et des procédés associés destinés à un nouveau récepteur de cytokine appelé zalpha11. Les polypeptides peuvent être utilisés dans des procédés permettant de détecter des ligands qui stimulent la prolifération et/ou la croissance de cellules hématopoïétiques, lymphoïdes et myéloïdes in vitro et in vivo. Les polypeptides du récepteur de liaison des ligands peuvent également être utilisés pour bloquer l'activité du ligand in vitro et in vivo. Les polynucléotides codant zalpha11 sont situés sur le chromosome et peuvent être utilisés pour identifier une région du génome associée à des pathologies humaines. La présente invention concerne également des procédés de production de la protéine, les utilisations associées et les anticorps correspondants.

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