Cytokine receptor zcytor17

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2412239

Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro andin vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

L'invention concerne de nouveaux polypeptides et des polynucléotides codant les polypeptides ainsi que des compositions associées et des procédés pour le zcytor17, un nouveau récepteur de la cytokine. Ces polypeptides peuvent servir dans des procédés permettant de détecter des ligands qui stimulent la prolifération et/ou le développement de cellules myéloïdes, lymphoïdes et hématopoïétiques <i>in vitro</i> et <i>in vivo</i>. Les polypeptides de récepteur de liaison avec des ligands peuvent également servir à bloquer l'activité des ligands <i>in vitro</i> et <i>in vivo</i>. Les polynucléotides codant le zcytor17 se trouvent sur le chromosome 5 et peuvent permettre d'identifier une région du génome associée à des états de maladie humaine. L'invention concerne également des procédés de fabrication de la protéine, des utilisations correspondantes et des anticorps associés.

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