Cytokine receptor zcytor17 multimers

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/19 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2473733

Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

L'invention porte sur de nouvelles combinaisons polypeptidiques, sur des polynucléotides codant les polypeptides et sur des compositions et procédés apparentés s'appliquant aux récepteurs multimères ou hétérodimères des cytokines contenant zcytor17, ces récepteurs pouvant être utilisés comme de nouveaux antagonistes des cytokines. L'invention porte également sur des procédés de détection de ligands qui stimulent la prolifération et/ou le développement des cellules hématopoïétiques, lymphoïdes et myéloïdes <i>in vitro</i> et <i>in vivo</i>. La présente invention porte enfin sur des procédés de production du récepteur multimère ou hétérodimère des cytokines, sur ses utilisations et sur les anticorps liés à celui-ci.

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