Cytokine-, stress-, and oncoprotein-activated human protein...

Details Cytokine-, stress-, and oncoprotein-activated human protein... Cytokine-, stress-, and oncoprotein-activated human protein...

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 38/45 (2006.01) C07H 21/00 (2006.01) C07K 14/075 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2219487

Disclosed are human mitogen-activated (MAP) kinase kinase isoforms (MKKs). MKKs mediate unique signal transduction pathways that activate human MAP kinases p38 and JNK, which result in activation of other factors, including activating transcription factor-2 (ATF2) and c-Jun. The pathways are activated by a number of factors, including cytokines and environmental stress. Methods are provided for identifying reagents that modulate MKK function or activity and for the use of such reagents in the treatment of MKK-mediated disorders.

L'invention se rapporte à des isoformes kinases de protéine kinase (MKK) humaine activées par les mitogènes (MAP). Ces MKK assurent la médiation des voies de transduction de signaux uniques qui activent les protéines kinases humaines activées par mitogènes MAP de type p38 et JNK, ce qui se traduit par l'activation d'autres facteurs, y compris celle du facteur 2 de transcription (ATF2) et de c-JUN. L'activation des voies obéit à un certain nombre de facteurs, y compris les cytokines et le stress dû à l'environnement. On décrit également des procédés qui permettent d'identifier les réactifs modulant la fonction ou activité propres aux isoformes MKK, et qui permettent d'utiliser ces réactifs dans le traitement des troubles à médiation MKK.

Affiliated with

Also associated with

Rating

Cytokine-, stress-, and oncoprotein-activated human protein... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cytokine-, stress-, and oncoprotein-activated human protein..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytokine-, stress-, and oncoprotein-activated human protein... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1452979