Cytokine synthesis inhibitory factor, antagonists thereof,...

Details Cytokine synthesis inhibitory factor, antagonists thereof,... Cytokine synthesis inhibitory factor, antagonists thereof,...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/04 (2006.01) A61K 38/19 (2006.01) C07K 7/04 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) C07K 16/24 (2006.01) C12N 15/70 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2062763

Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-.gamma..

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