Cytokine that induces apoptosis

Details Cytokine that induces apoptosis Cytokine that induces apoptosis

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2225378

A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.

Cette invention concerne une nouvelle cytokine, dénommée TRAIL, qui induit l'apoptose de certaines cellules cibles, et entre autres des cellules cancéreuses et des cellules infectées par un virus. L'invention se rapporte à des séquences d'ADN isolées qui codent cette cytokine TRAIL, ainsi qu'à des vecteurs d'expression et des cellules hôtes transformées qui s'avèrent utiles s'agissant de la production de polypeptides de cette cytokine TRAIL. L'invention concerne en outre des anticorps qui se lient spécifiquement à cette cytokine TRAIL.

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